Fachbereich Physik

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Harmonic nanocrystals

They are based on materials like LiNbO3 or KNbO3. Thanks to a lack of symmetry in the crystal structure, they show several nonlinear effects like second harmonic, third harmonic, sum and difference frequency generation. The possibility to decrease their size in the nanoscale opens the possibility for new intriguing physical effects and applications.

The research focuses on their bio-oriented applications as nonlinear marker, indeed they are well suited for in-vivo deep imaging. In this respect, we recently demonstrated that they are the only marker that can be used in the fourth biological window (NIR-IV 2100-2300nm), a spectral region which is gaining interest in the recent years for safe in-vivo studies. 


Nonlinear microscopy

This microscopy technique is based on the use of femtosecond pulsed laser as light source.  It become pupolar in the last decades because it allows higher penetration depth, 3D imaging, better signal to noise ratio and photodamage limited to the focal point. This  technology is still evolving since its original appeareance and nowdays it is possible to have lasers with several adjustable parameters (wavelength, repetition rate, energy per pulse, etc..) in one single turn-key device offering access to new experimental configurations.

This research focuses on these unexplored laser configurations and their advantages in microscopy studies. In particular, the commercial techniques work with laser having an energy per pulse in the nanoJoule regime while here the attention is devoted to a configuration exploiting microJoule. This is the key concept of the new conceived TIGER microscope installed in the CellNanOs facility.